Millipore Sigma Vibrant Logo

07-217-I Anti-NAG-1/GDF15

Detect Growth/differentiation factor 15 using this rabbit polyclonal Anti-NAG-1/GDF15, Cat. No. 07-217-I, useing Immunohistochemistry (Paraffin) and Western Blotting.

Anti-NAG-1/GDF15 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Gene Symbol: GDF15, MIC1, PDF, PLAB, PTGFB UniProt Number: Q99988
View Products on Sigmaaldrich.com
07-217-I
100 μg  
Retrieving price...
Price could not be retrieved
Minimum Quantity is a multiple of
Maximum Quantity is
Upon Order Completion More Information
You Saved ()
 
—
Request Pricing
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

       

      Contact Customer Service

      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-217-I
      Replaces07-217
      DescriptionAnti-NAG-1/GDF15
      Alternate Names
      • Macrophage inhibitory cytokine 1
      • MIC-1
      • NSAID-activated gene 1 protein
      • NAG-1
      • NSAID-regulated gene 1 protein
      • NRG-1
      • Placental TGF-beta
      • Placental bone morphogenetic protein
      • Prostate differentiation factor
      Background InformationGrowth/differentiation factor 15 (UniProt: Q99988; also known as GDF-15, Macrophage inhibitory cytokine 1, MIC-1, NSAID-activated gene 1 protein, NAG-1, NSAID-regulated gene 1 protein, NRG-1, Placental TGF-beta, Placental bone morphogenetic protein, and Prostate differentiation factor) is encoded by the GDF15 (also known as MIC1, PDF, PLAB, PTGFB) gene (Gene ID: 9518) in human. NAG-1 is a member of the TGF-beta super family, however, it does not display strong homology to existing families. NAG-1 is synthesized as a 308-amino acid pro-NAG-1 monomer and then dimerizes by a specific disulfide linkage. The pro-NAG-1 dimer is then cleaved by furin-like proteases at an RXXR site, forming a 112 amino acid C-terminal dimeric protein and pro-peptide. It is expressed in placenta and is found in lower levels in prostate, kidney, and colon. Its expression is significantly increased during inflammation, injury, and malignancy. Increase of NAG-1 expression is a feature of many cancers including breast, colon, pancreas and prostate. NAG-1 expression is also shown to increase following exposure to a number of non-steroidal anti-inflammatory drugs. Induced expression of NAG-1 is shown to result in stimulation of apoptosis and inhibition of cell growth.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Growth/differentiation factor 15 using this rabbit polyclonal Anti-NAG-1/GDF15, Cat. No. 07-217-I, useing Immunohistochemistry (Paraffin) and Western Blotting.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesWestern Blotting Analysis: 2 µg/mL from a representative lot detected NAG-1/GDF15 in 10 µg of HepG2 conditioned media.



      Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected NAG-1/GDF15 in human placenta tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to 16 amino acids from the C-terminal end of human NAG-1/GDF15.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis polyclonal antibody specifically detects Growth/differentiation factor 15 in human.
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • GDF15
      • MIC1
      • PDF
      • PLAB
      • PTGFB
      Purification MethodAffinity Purified
      UniProt Number
      Molecular Weight34.14 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in LNCap Conditioned Media.

      Western Blotting Analysis: 2 µg/mL of this antibody detected NAG-1/GDF15 in 10 µg of LNCap Conditioned Media.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      07-217-I 04054839168772